VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases

MF Neurath, LJ Berg

Trends in Immunology

Immune landscape of Epstein–Barr virus–associated gastric cancer: analysis from a western academic institution

EJ Yee, D Gilbert, J Kaplan, L van Dyk, SS Kim, L Berg, E Clambey, ...

Journal of Surgical Research 296, 742-750

Investigating immunity: uncovering the mechanisms of the immune system

LJ Berg, AP Bernard

https://doi.org/10.33424/FUTURUM391

Tunable B cell response through allosteric modulation of Bruton’s tyrosine kinase

A Reboldi, A Berthelette, N Kolli, N Amatya, A Andreotti, LJ Berg, S Der, ...

The Journal of Immunology 210 (Supplement_1), 154.19-154.19

Analysis of T-cell receptor-induced calcium influx in primary murine T-cells by full Spectrum flow cytometry

L Perrenoud, J Conley, LJ Berg

Journal of visualized experiments: JoVE, 10.3791/64526

Interplay between IL-10, IFN-γ, IL-17A and PD-1 Expressing EBNA1-Specific CD4+ and CD8+ T Cell Responses in the Etiologic Pathway to Endemic Burkitt …

CS Forconi, DH Mulama, P Saikumar Lakshmi, J Foley, JA Otieno, ...

Cancers 13 (21), 5375

Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK

MP Gallagher, JM Conley, P Vangala, M Garber, A Reboldi, LJ Berg

Proceedings of the National Academy of Sciences 118 (35), e2025825118

Optimized detection of acute MHV68 infection with a reporter system identifies large peritoneal macrophages as a dominant target of primary infection

JB Riggs, EM Medina, LJ Perrenoud, DL Bonilla, ET Clambey, ...

Frontiers in Microbiology 12, 656979

Interplay between IL-10, IFN-γ, IL-17A and PD-1 Expressing EBNA1-Specific CD4+ and CD8+ T Cell Responses in the Etiologic Pathway to Endemic Burkitt Lymphoma. Cancers 2021, 13 …

CS Forconi, DH Mulama, P Saikumar Lakshmi, J Foley, JA Otieno, ...

The Tec kinase ITK differentially optimizes NFAT, NF-κB, and MAPK signaling during early T cell activation to regulate graded gene induction

MP Gallagher, JM Conley, P Vangala, A Reboldi, M Garber, LJ Berg

bioRxiv, 2020.11. 12.380725

Activation of the Tec kinase ITK controls graded IRF4 expression in response to variations in TCR signal strength

JM Conley, MP Gallagher, A Rao, LJ Berg

The Journal of Immunology 205 (2), 335-345

CD8+ T cells require ITK-mediated TCR signaling for migration to the intestine

HS Cho, S Ha, HM Shin, A Reboldi, JA Hall, JR Huh, EJ Usherwood, ...

Immunohorizons 4 (2), 57-71

TCR signaling: It’s all about the numbers

JM Conley, LJ Berg

Nature immunology 20 (11), 1415-1416

The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine

HS Cho, A Reboldi, JA Hall, LJ Berg

Nature communications 10 (1), 784

The transcription factor Runx2 is required for long-term persistence of antiviral CD8+ memory T cells

E Olesin, R Nayar, P Saikumar-Lakshmi, LJ Berg

Immunohorizons 2 (7), 251-261

Peptide antigen concentration modulates digital NFAT1 activation in primary mouse naive CD8+ T cells as measured by flow cytometry of isolated cell nuclei

MP Gallagher, JM Conley, LJ Berg

Immunohorizons 2 (7), 208-215

Multidomain control over TEC kinase activation state tunes the T cell response

AH Andreotti, RE Joseph, JM Conley, J Iwasa, LJ Berg

Annual Review of Immunology 36 (1), 549-578

On the Horizon

L Berg, M Krangel

ImmunoHorizons 2 (1), 26-26

Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory

HM Shin, VN Kapoor, G Kim, P Li, HR Kim, M Suresh, SM Kaech, ...

PLoS pathogens 13 (8), e1006544

High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells

YT Falanga, M Frascoli, Y Kaymaz, C Forconi, JM Ong’echa, JA Bailey, ...

JCI insight 2 (15), e93814

Gene-enhancer variants reveal diverse TCR-mediated differentiation

MP Gallagher, LJ Berg

Nature Immunology 18 (5), 483-484

NKG2C/E marks the unique cytotoxic CD4 T cell subset, ThCTL, generated by influenza infection

NB Marshall, AM Vong, P Devarajan, MD Brauner, Y Kuang, R Nayar, ...

The Journal of Immunology 198 (3), 1142-1155

Treating organ-specific t cell mediated autoimmune diseases

J Kang, L Berg, N Jain

US Patent App. 15/027,399

II-13 Suppression of systemic autoimmunity by the innate immune adaptor sting

S Sharma, AM Campbell, J Chan, SA Schattgen, GM Orlowski, R Nayar, ...

Lupus Science & Medicine 3 (Suppl 1)

Type 1 interferon licenses naïve CD8 T cells to mediate anti-viral cytotoxicity

SL Urban, LJ Berg, RM Welsh

Virology 493, 52-59

T cells and gene regulation: the switching on and turning up of genes after T cell receptor stimulation in CD8 T cells

JM Conley, MP Gallagher, LJ Berg

Frontiers in Immunology 7, 76

IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8+ T Cells Responding to Persistent LCMV Infection

R Nayar, E Schutten, S Jangalwe, PA Durost, LL Kenney, JM Conley, ...

PloS one 10 (12), e0144826

A small molecule inhibitor of ITK and RLK impairs Th1 differentiation and prevents colitis disease progression

HS Cho, HM Shin, H Haberstock-Debic, Y Xing, TD Owens, JO Funk, ...

The Journal of Immunology 195 (10), 4822-4831

TCF1 is required for the T follicular helper cell response to viral infection

T Wu, HM Shin, EA Moseman, Y Ji, B Huang, C Harly, JM Sen, LJ Berg, ...

Cell reports 12 (12), 2099-2110

94 A Covalent Inhibitor of ITK and RLK Inhibits Th1 and Th17 Cell Differentiation and Prevents Disease Manifestation in an Adoptive Transfer Model of Colitis

HS Cho, J Conley, HM Shin, H Haberstock-Debic, KA Brameld, TD Owens, ...

Gastroenterology 148 (4), S-27

Suppression of systemic autoimmunity by the innate immune adaptor STING

S Sharma, AM Campbell, J Chan, SA Schattgen, GM Orlowski, R Nayar, ...

Proceedings of the National Academy of Sciences 112 (7), E710-E717